Researchers find link between artificial sweeteners and heart disease
A potential direct association between higher artificial sweetener consumption and increased cardiovascular disease risk, including heart attack and stroke has been uncovered by a large study of French adults published on September 7 by The BMJ.
These food additives are consumed daily by millions of people and are present in thousands of foods and drinks. The findings indicate that these artificial sweeteners should not be considered a healthy and safe alternative to sugar, in line with the current position of several health agencies.
Artificial sweeteners are widely used as no or low-calorie alternatives to sugar. They represent a $7.2 billion (£5.9 billion; €7.0 billion) global market and are found in thousands of products worldwide. They are particularly common in ultra-processed foods such as artificially sweetened drinks, some snacks, and low-calorie ready meals.
Several studies have already linked the consumption of artificial sweeteners or artificially sweetened beverages to weight gain, high blood pressure, and inflammation.
To investigate this further, a team of researchers at the French National Institute for Health and Medical Research (Inserm) and colleagues, drew on data from 103,388 participants (average age 42 years; 80% female) of the web-based NutriNet-Santé study. Launched in France in 2009, this ongoing study investigates relations between nutrition and health.
Dietary intakes and consumption of artificial sweeteners were assessed by repeated 24-hour dietary records. A wide range of potentially influential health, lifestyle, and sociodemographic factors were taken into account.
Artificial sweeteners from all dietary sources (beverages, dairy products, tabletop sweeteners, etc.) and by type (aspartame, sucralose, and acesulfame potassium) were included in the analysis.
A total of 37% of participants consumed artificial sweeteners, with an average intake of 42.46 mg/day. This corresponds to approximately one individual packet of tabletop sweetener or 100 mL (3.4 ounces) of diet soda.
Among participants who consumed artificial sweeteners, mean intakes for lower and higher consumer categories were 7.46 and 77.62 mg/ day, respectively.
During an average follow-up period of nine years, 1,502 cardiovascular events occurred. They included heart attack, angioplasty (a procedure to widen blocked or narrowed arteries to the heart), angina, transient ischemic attack, and stroke.
The scientists found that total artificial sweetener intake was associated with an increased risk of cardiovascular disease (absolute rate 346 per 100,000 person-years in higher consumers and 314 per 100,000 person-years in non-consumers).
Artificial sweeteners were more particularly associated with cerebrovascular disease risk (absolute rates 195 and 150 per 100,000 person-years in higher and non-consumers, respectively).